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It has collaborated with the greatest Greek artists (notable mentions include: Mikis Theodorakis, Manos Chadjidakis, Melina Merkouri, Manos Loizos, Fleri Dadonaki, Mimis Plessas, Christos Nikolopoulos, Dimitris Mitropanos, Thanos Mikroutsikos, Vasilis Papakonstantinou, Pix Lax, Haris Alexiou, Dimitra Galani, Stefanos Korkolis, Lavrentis Maxairitsas, Tania Tsanaklidou, Haris & Panos Katsimihas, Manolis Mitsias, etc), as well as important artists from the international artistic scene (notable mentions include: Vanessa Mae, Montserrat Caballe, Alexandre Desplat, Cesaria Evora, Sinead O'Connor, Stomp, Patricia Kaas, Jethro Tull, Billy Idol, The Stranglers, etc.).

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It has also collaborated with a large number of cultural organizations and Institutions (including "Athens 2004," which entrusted it with a significant portion of the cultural program for the 2004 Olympic Games), and its activities have surpassed the geographical boundaries of Greece, having toured with some of the most important Greek artists in Europe, North America and Canada.

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With the experience and expertise it has gained over the years, Music Box operates in the field with respect for the audience, aiming to fully meet their needs.